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Journal of Pharmacology And Experimental Therapeutics, Vol. 76, Issue 4, 343-354, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

CHANGES IN THE BLOOD PICTURE OF THE DOG FOLLOWING SUBCUTANEOUS INJECTIONS OF SODIUM SELENITE

H. D. ANDERSON 1 and A. L. MOXON 1

1 S. Dak. Agric. Exp't. Sta., Brookings, S. Dak.

(1) The minimal fatal dose of sodium selenite for the dog under barbital depression lies between 1.5 and 2.0 mgm. of selenium per kgm. of body weight when injected subcutaneously.

(2) Changes in the blood picture following such an injection are:

a. A marked increase in hemoglobin and hematocrit values, as much as 62%.

b. A decrease in inorganic phosphorus, non-protein nitrogen, ascorbic acid and blood sugar which is greater than might be explained by the fluid loss.

c. Preliminary data indicate a similar fall in glutathione concentration.

d. Blood pressure is not greatly affected until shortly before death, when it falls rapidly.

(3) Three relatively resistant dogs were encountered, two of which showed high values for plasma-ascorbic acid and the other showed high values for blood sugar.

(4) Efforts were made to increase the resistance of dogs by injecting ascorbic acid in M/15 phosphate buffer. Results indicate a favorable response when the selenium dosage was approximately 1 minimum fatal dose, since the usual increase in concentration of the formed elements was prevented or greatly reduced.

Submitted on August 19, 1942






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.