SOME NEW ASPECTS OF MORPHINE ACTION: EFFECT ON THE STOMACH

¹ From the Laboratory of Physiology and Pharmacology, Baylor University College of Medicine, Dallas, Texas

1. In appropriate subcutaneous and intravenous doses prostigmine methylsulfate is inhibitory to the tonus and contractions of the stomach in unanesthetized dogs.

2. When inactive doses of morphine are given following subliminal doses of prostigmine methylsulfate, a typical morphine-like effect is seen in the stomach of unanesthetized dogs. This is followed by a rise in the tonus and by rhythmical activity increased above the normal level.

3. Individually inactive doses of morphine and prostigmine methylsulfate combined in one injection produce a typical morphine-like effect on the stomach.

4. These results indicate that the effect of morphine on the stomach resembles that of a cholinergic drug and that it is potentiated by prostigmine.

5. Using the dog, we cannot confirm the reports of Veach, et al., and of Hamilton and Curtis, that prostigmine methylsulfate reverses the action of atropine in the human stomach.

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