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Journal of Pharmacology And Experimental Therapeutics, Vol. 76, Issue 3, 275-281, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

A DEVICE FOR THE CONTINUOUS RECORDING OF HEART RATE: ITS APPLICATION TO A STUDY OF THE CIRCULATORY EFFECTS OF EPINEPHRINE AND CARBAMINOYL CHOLINE

MICHAEL KNIAZUK 1 and KLAUS UNNA 1

1 From the Merck Institute for Therapeutic Research, Rahway, N. J.

1. A method is described which permits the continuous recording of the heart rate on an ordinary smoked paper or ink kymograph.

2. Epinephrine (40 micrograms) and carbaminoyl choline (1-10 micrograms) decrease the heart rate. The depression of the heart rate due to vagal stimulation lasts considerably longer than the concomitant changes in the blood pressure.

3. In the atropinized cat, the increase in the heart rate following epinephrine is of the same duration as the increase in blood pressure.

Submitted on August 11, 1942






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.