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Journal of Pharmacology And Experimental Therapeutics, Vol. 76, Issue 3, 235-239, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE FATE OF NICOTINE IN THE BODY I. THE EFFECT OF pH ON THE URINARY EXCRETION OF NICOTINE BY TOBACCO SMOKERS

H. B. HAAG 1 and P. S. LARSON 1

1 From the Department of Pharmacology, Medical College of Virginia, Richmond

1. Nicotine has been determined quantitatively in human urine by a modified silicotungstic acid method.

2. During the periods when the urine was alkaline, the amount of nicotine excreted by tobacco smokers was only 25% of that noted when the urine was acid, presumably because of reabsorption of the nicotine from the urinary tract.

3. Data are presented supporting the view that some potent mechanism other than urinary excretion is active in the disposal of nicotine by tobacco smokers.

4. In studies of the quantitative urinary elimination of chemicals generally the possible influence of urinary pH on their resorption from the urinary tract might well be borne in mind.

Submitted on July 31, 1942




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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.