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Journal of Pharmacology And Experimental Therapeutics, Vol. 76, Issue 2, 202-206, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

THE EXPERIMENTAL PRODUCTION OF PRIMARY OPTIC ATROPHY IN MONKEYS BY ADMINISTRATION OF ORGANIC ARSENICAL COMPOUNDS

B. J. LONGLEY 1, N. M. CLAUSEN 1, and A. L. TATUM 1

1 From the Department of Pharmacology, University of Wisconsin, Madison

1. Blindness has been produced in monkeys by the administration of the following compounds: atoxyl, tryparsamide, stovarsol, 3-amino-4-beta-hydroxy-ethoxy-phenylarsonic acid (No. 190), and 4-beta-(beta'-hydroxy)ethoxy-ethoxy-phenylarsonic acid (No. 266), the last containing no nitrogen in the molecule.

2. The work herein reported would appear to provide an experimental basis for detecting the blinding potentialities of arsenical compounds for man.

3. Means now become available for a study of prophylactic procedures designed to reduce or eliminate optic atrophy as a sequence of chemotherapy of neurosyphilis.

Submitted on July 17, 1942




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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.