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Journal of Pharmacology And Experimental Therapeutics, Vol. 76, Issue 2, 194-201, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

THE ANTICONVULSANT ACTION OF DIPHENYL HYDANTOIN AND SOME RELATED COMPOUNDS

P. K. KNOEFEL 1 and G. LEHMANN 1

1 From the Department of Pharmacology, University of Louisville School of Medicine, Louisville, Kentucky

Diphenyl hydantoin raises the threshold of electrically produced convulsions in cats. This anticonvulsant activity is not seen in decerebrate cats.

Diphenyl hydantoin does not prevent the convulsions caused by strychnine and cocaine.

Diphenyl hydantoin does not appear as such in the urine of rabbits and dogs receiving large amounts of it.

Diphenylacetyl urea and diphenyl thiohydantoin are devoid of anticonvulsant activity. Diphenyl barbituric acid has from one-fourth to one-half the anticonvulsant activity of diphenyl hydantoin, and an equal acute toxicity. Diphenylene hydantoin has from one-fourth to one-half the anticonvulsant activity, and more than one-half the acute and chronic toxicity, of diphenyl hydantoin. Fluorenone has, on oral administration of large amounts, a slowly developing anticonvulsant activity.

Submitted on June 29, 1942




This article has been cited by other articles:


Home page
 Arch NeurolHome page
R. P. Bazemore and E. C. Zuckermann
On the Problem of Diphenylhydantoin-Induced Seizures: An Experimental Approach
Arch Neurol, October 1, 1974; 31(4): 243 - 249.
[Abstract] [PDF]


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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.