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Journal of Pharmacology And Experimental Therapeutics, Vol. 76, Issue 2, 189-193, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

THE PARENTERAL USE OF ORGANIC ESTERS

W. L. LIPSCHITZ 1, S. D. UPHAM 1, C. N. HOTCHKISS 1, and G. H. CARLSON 1

1 From Lederle Laboratories, Inc., Pearl River, N. Y.

1. The applicability of organic esters as solvents for water-insoluble preparations administered parenterally has been tested.

2. Twenty-five liquid organic esters have been systematically examined for systemic toxicity, local irritation and the action upon neuromuscular functions when injected into the gluteal muscles of guinea-pigs.

3. Butyl succinate and ethyl pimelate proved least toxic and were suitable for parenteral use.

Submitted on June 25, 1942






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.