SYNTHETIC DERIVATIVES OF STROPHANTHIDIN

¹ From the Lilly Research Laboratories, Indianapolis, and the Department of Chemistry, Columbia University, New York City

1. Strophanthidin acetate and 7 synthetic glycosides of strophanthidin all have a digitalis-like action.

2. When assayed in cats and frogs, strophanthidin acetate, strophanthidin--d-glucoside, -d-xyloside, and -l-arabinoside, prove more potent than strophanthidin. Strophanthidin--tetraacetyl-d-glucoside, -triacetyl-d-xyloside, -triacetyl-l-arabinoside, and -tetraacetyl-d-galactoside, on the other hand, are weaker than strophanthidin.

3. Strophanthidin--d-glucoside and -l-arabinoside are also more potent than cymarin, the natural glycoside from which strophanthidin is originally obtained. Strophanthidin--d-xyloside is at least as active as cymarin.