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Journal of Pharmacology And Experimental Therapeutics, Vol. 76, Issue 1, 21-26, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

EVIDENCE OF ANOTHER PHYSIOLOGICALLY ACTIVE PRINCIPLE IN CANNABIS SATIVA (MARIHUANA)

GORDON A. ALLES 1, A. J. HAAGEN-SMIT 1, GEORGE A. FEIGEN 1, and WALTER B. DANDLIKER 1

1 From the William G. Kerckhoff Laboratories of the Biological Sciences, California Institute of Technology, Pasadena

1. Alcoholic extracts of Cannabis of American origin may vary considerably im their relative activities, as measured by the dog incoordination and rabbit corneal anesthesia tests.

2. This variation may be due to variation in the extracted materials, but can be entirely due to exposure to air under moderate conditions of time and temperature.

3. Deterioration of Cannabis extracts under such conditions may lead to loss of significant activity in the rabbit without notable loss of activity in the dog.

4. The corneal anesthesia activity in the rabbit of Cannabis extracts would therefore appear to be due to an active principle not yet isolated, for the active substances that have been isolated all exhibit considerable dog incoordination activity.

Submitted on May 12, 1942






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.