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Journal of Pharmacology And Experimental Therapeutics, Vol. 76, Issue 1, 17-20, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE TOLERANCE FORMATION TO GOLD SODIUM THIOSULPHATE IN RATS

RUTH CORTELL 1 and R. KOHN RICHARDS 1

1 From the Abbott Laboratories, North Chicago, Illinois

Tolerance formation to usually fatal amounts of gold sodium thiosulphate in rats can be developed by the repeated intramuscular injection of doses ranging from 20 to 35 mgm./kgm.

The mechanism of the tolerance formation is related to the development of a resistance of the epithelial cells of the tubules of the kidney to the damaging effects of the gold salt.

Submitted on May 11, 1942






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.