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Journal of Pharmacology And Experimental Therapeutics, Vol. 75, Issue 3, 363-366, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

A STUDY OF THE COMPARATIVE TOXIC EFFECTS OF MORPHINE ON THE FETAL, NEWBORN AND ADULT RATS

ANNETTE CHESLER 1, GILES C. LABELLE 1, and HAROLD E. HIMWICH 1

1 Department of Physiology and Pharmacology, Albany Medical College, Union University, Albany, New York

Lethal doses of morphine sulphate were administered to 116 adult rats, 300 newborn rats, and 11 pregnant rats at full term. The newborn rats were more resistant to acute respiratory failure than the adult rats, but the fetuses were about equal in susceptibility to their mothers. Probable causes for the characteristic susceptibility of fetal, newborn, and adult rats to lethal doses of morphine are discussed.

Submitted on April 30, 1942






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.