JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SESLER, C. L.
Right arrow Articles by SCHMIDT, L. H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by SESLER, C. L.
Right arrow Articles by SCHMIDT, L. H.
Journal of Pharmacology And Experimental Therapeutics, Vol. 75, Issue 3, 356-362, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON SULFONAMIDE-RESISTANT ORGANISMS: II. COMPARATIVE DEVELOPMENT OF RESISTANCE TO DIFFERENT SULFONAMIDES BY PNEUMOCOCCI

CLARA L. SESLER 1 and L. H. SCHMIDT 1

1 From The Institute for Medical Research, Christ Hospital, Cincinnati, Ohio

A study of some of the factors involved in the development of sulfonamide-resistant pneumococci showed the following:

(1) Strains of pneumococcus differed in the ease with which they developed resistance to a given sulfonamide.

(2) There was a difference in the rates at which a single strain of pneumococcus developed resistance to the various sulfonamides. In all instances, resistance was developed most rapidly to the least effective drug and most slowly to the most effective drug.

(3) When a strain of pneumococcus had acquired resistance to one sulfonamide, it was also resistant to all the other sulfonamides tested.

Submitted on April 24, 1942






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.