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Journal of Pharmacology And Experimental Therapeutics, Vol. 75, Issue 3, 289-298, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES ON l-N-ETHYLEPHEDRINE HYDROCHLORIDE

T. J. BECKER 1, M. R. WARREN 1, D. G. MARSH 1, C. R. THOMPSON 1, and R. S. SHELTON 1

1 Department of Pharmacology, Research Laboratories of the Wm. S. Merrell Company, Cincinnati, Ohio

The toxicological and pharmacological actions of l-N-ethylephedrine have been described and compared with those of l-ephedrine.

The toxicity of this compound is of the same order as that of l-ephedrine.

The effect on the cardiovascular system is less than that elicited by similar amounts of l-ephedrine whereas the effect on the bronchioles is approximately the same.

l-N-Ethylephedrine appears to have a greater effect on the intestinal and uterine muscle than l-ephedrine.

This compound produces a minimum of central stimulation.

An attempt has been made to correlate the pharmacological actions of l-N-ethylephedrine with its chemical structure.

Submitted on February 13, 1942






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.