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Journal of Pharmacology And Experimental Therapeutics, Vol. 75, Issue 3, 247-250, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

VISCERAL LESIONS ASSOCIATED WITH TRIBROMETHANOL ADMINISTERED RECTALLY

A. H. MALONEY 1

1 From the Department of Pharmacology of Howard University School of Medicine, Washington, D. C.

1. Avertin administered rectally to rabbits in sub-lethal doses or in lethal doses which are effectively antidoted by picrotoxin so as not to cause acute death by systemic intoxication, produces a delayed death by rectal irritation, inflammation, ulceration and sometimes perforation.

2. This intestinal lesion is associated with analogous degenerative visceral changes chiefly in the heart, the kidney, the brain, and the liver.

3. The immediate cause of death is either perforation of the intestine followed by peritonitis or excruciating pain on defecation.

Submitted on March 9, 1942




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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.