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Journal of Pharmacology And Experimental Therapeutics, Vol. 75, Issue 3, 226-230, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

DISTRIBUTION OF EXOGENOUS BROMINE IN CATS AFTER TREATMENT WITH TRIBROMOETHANOL, TRIBROMOACETALDEHYDE AND TRIBROMOACETIC ACID

G. A. EMERSON 1 and JAMES L. MORRISON 1

1 From the Department of Pharmacology, West Virginia University School of Medicine, Morgantown

Distribution of exogenous bromine in tissues of cats is described after treatment of these animals with tribromoethanol, tribromoacetaldehyde and tribromoacetic acid. Avertin is distributed in most tissues in greater concentration than in blood, while the reverse holds for the latter two agents. The central nervous system has a high affinity for avertin but not for bromal and tribromoacetic acid. Several tissues other than brain exhibit higher affinities for each of the agents than does the brain. Absorption of any one agent is variable but the relative distribution of absorbed amounts is constant.

Submitted on February 20, 1942






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.