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Journal of Pharmacology And Experimental Therapeutics, Vol. 75, Issue 2, 137-144, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

ANIMAL STANDARDS FOR ACUTE TOXICITY OF SPINAL ANESTHETIC AGENTS

CO TUI 1, A. L. PREISS 1, C. L. BURSTEIN 1, and W. F. RUGGIERO 1

1 From the laboratory of Experimental Surgery, and the Division of Anesthesia, Department of Surgery, New York University College of Medicine, New York City

1. The intraspinal MLC of 2 well-known local anesthetics, procaine-hydrochloride and nupercaine, and of one new local anesthetic, monócaine formate, was determined in rabbits and cats.

2. In the determination of the intraspinal MLC, the spinal length is a consistent basis for the calculation of dosage for both the rabbit and the cat.

3. A new local anesthetic, monócaine formate, according to the criteria used in this study seems as effective as, and safer than, procaine-hydrochloride.

Submitted on February 5, 1942






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