JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SACHS, E.
Right arrow Articles by YONKMAN, F. F.
Right arrow Search for Related Content
PubMed
Right arrow Articles by SACHS, E.
Right arrow Articles by YONKMAN, F. F.
Journal of Pharmacology And Experimental Therapeutics, Vol. 75, Issue 2, 105-110, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGICAL BEHAVIOR OF THE INTRAOCULAR MUSCLESV. THE ACTION OF YOHIMBINE AND ERGOTAMINE ON THE DILATOR IRIDIS

E. SACHS 1 and F. F. YONKMAN 1

1 From the Ophthalmic Research Laboratory and the Department of Pharmacology, Wayne University, College of Medicine, Detroit

1. Yohimbine antagonizes the action of adrenalin upon the excised dilator iridis of albino rabbits, without reversing the adrenalin effect.

2. Yohimbine, when used alone, has no discernible influence upon the dilator.

3. Ergotamine is a powerful antagonist of adrenalin and can reverse the normal effect of a subsequent application of the latter drug.

4. Ergotamine, when used alone, has a slight, inconsistent stimulating effect upon the dilator.

5. Ergotamine, even though it contracts the dilator, does not act synergistically with adrenalin.

Submitted on October 23, 1941






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.