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Journal of Pharmacology And Experimental Therapeutics, Vol. 75, Issue 1, 89-104, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

SULFONAMIDE THERAPY OF MALARIA IN DUCKS

E. K. MARSHALL JR. 1, J. T. LITCHFIELD JR. 1, and H. J. WHITE 1

1 From the Department of Pharmacology and Experimental Therapeutics, Johns Hopkins University, Baltimore, Maryland

The maintenance of a more or less constant blood concentration of a sulfonamide drug for a sufficient length of time is just as important for effective therapy in P. lophurae infections in ducks as it is in bacterial chemotherapy. The degree of parasitemia in treated ducks at the time when untreated birds are at the height of their parasitemia can be used as a criterion of effectiveness of therapy. Under our experimental conditions, the degree of parasitemia on the sixth day after infection was correlated with survival time and percentage survival. The antimalarial activity of a number of sulfonamides and sulfones has been tested. Para-aminobenzoic acid has slight antimalarial activity, and has a definite antagonistic effect on the antimalarial action of sulfonamide drugs.

Submitted on February 11, 1942




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J. H. SANDGROUND
p-AMINOBENZOIC ACID DETOXICATION OF CARBARSONE (p-CARBAMINO PHENYL ARSONIC ACID) AND CERTAIN OTHER PENTAVALENT PHENYL ARSONATES ADMINISTERED IN MASSIVE DOSES TO RATS
Science, January 15, 1943; 97(2507): 73 - 74.
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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.