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Journal of Pharmacology And Experimental Therapeutics, Vol. 75, Issue 1, 69-77, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF SENECIONINE, INTEGERRIMINE, JACOBINE, LONGILOBINE, AND SPARTIOIDINE, ESPECIALLY ON THE LIVER

PAUL N. HARRIS 1, ROBERT C. ANDERSON 1, and K. K. CHEN 1

1 From the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

1. The median lethal doses of senecionine, integerrimine, jacobine, longilobine, and spartioidine, have been determined in mice by intravenous injection. Death occurs in 24-96 hours following medication.

2. Necropsies have been performed on all animals, dead or surviving for a week. Necrosis of the liver, chiefly central, associated with sinusoidal congestion and hemorrhage into cell cords is uniformly observed.

3. Repeated administration of small sublethal doses of the 5 alkaloids, intravenously, subcutaneously, or orally, is followed by hypertrophy of the liver cells and their nuclei. In no instance is cirrhosis of the liver observed.

4. All the 5 alkaloids lower arterial blood pressure of etherized cats, and inhibit the peristaltic movements of isolated rabbits' intestines. Integerrimine, longilobine, and jacobine cause contractions of isolated guinea pigs' uteri.

Submitted on February 2, 1942




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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.