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Journal of Pharmacology And Experimental Therapeutics, Vol. 75, Issue 1, 18-29, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF SOME ANAESTHETIC AGENTS ON THE VOLUME OF BODY FLUID

D. D. BONNYCASTLE 1

1 From the Department of Pharmacology, University of Toronto

The evidence presented above certainly suggests that ether, even with morphine and atropine premedication, would not be advisable in the case of shock, owing to the fact that plasma volume is decreased and also that there is a decrease in interstitial fluid which may be secondary to the deranged cellular metabolism.

The evidence for both nitrous oxide and cyclopropane appears much more favourable. Both the barbiturates increased plasma volume with little change in blood volume, yet their value is more difficult to assess as the decrease in interstitial fluid was not significant.

Submitted on January 2, 1942




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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.