THE ANTI-HISTAMINE ACTIVITY OF THYMOXYETHYLDIETHYL-AMINE AND N'ETHYL-N'DIETHYLAMINOETHYLANILINE AS JUDGED BY THE GASTRIC RESPONSE TO HISTAMINE

¹ From the Department of Physiology, University of Minnesota, Minneapolis

The substances, thymoxyethyldiethylamine and N'ethyl-N'-diethylaminoethylaniline, have not had demonstrable specific histamine antagonism, as tested by the gastric secretory response of Heidenhain pouch dogs to histamine stimulation. This fact, together with a survey of the reported work, would indicate to us that these materials have a non-specific protective action against smooth muscle contraction. It seems probable that they have a strong preferential inhibition on the histamine type of smooth muscle reaction. With large doses of thymoxyethyldiethylamine administered subcutaneously some evidence of lowered pain sensitivity was observed. No complete analgesia was noted.

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