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Journal of Pharmacology And Experimental Therapeutics, Vol. 74, Issue 4, 395-400, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

A MIXED COLOR DITHIZONE METHOD FOR THE DETERMINATION OF BISMUTH IN BIOLOGICAL MATERIAL

E. F. KLUCHESKY 1, B. J. LONGLEY 1, and F. L. KOZELKA 1

1 From the Department of Pharmacology and Toxicology, University of Wisconsin, Madison

A simplified mixed color dithizone method for the determination of bismuth in biological material is described. Treatment of the digest with sulfur dioxide prevents decomposition of the dithizone by the iron and eliminates tin as an interfering metal, hence permits the determination of bismuth with a single extraction. The method eliminates the necessity of removing the excess dithizone or preparing standard dithizone solutions. Consistent recoveries with a mean error of less than one microgram are obtainable.

Submitted on January 10, 1942






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.