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Journal of Pharmacology And Experimental Therapeutics, Vol. 74, Issue 4, 381-391, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF SIMPLE LACTONES RELATED TO CARDIAC AGLYCONES

K. K. CHEN 1, FRANK A. STELDT 1, JOSEF FRIED 1, and ROBERT C. ELDERFIELD 1

1 From the Lilly Research Laboratories, Indianapolis, and the Department of Chemistry, Columbia University, New York City

1. Twenty-seven unsaturated lactones related to cardiac aglycones have been studied pharmacologically.

2. beta,ggr-Angelica lactone, the lactone of 21-hydroxy-Dgr20,22-norcholenic acid, methyl coumalate, and ethyl coumalate, cause systolic standstill of frogs' ventricles when adequate doses are injected into the ventral lymph sac. beta-(beta-Naphthyl)-Dgragr,beta-butenolide has a suggestive action.

3. In cats, beta,ugr-angelica lactone and methyl and ethyl coumalates all produce a fall of blood pressure and fail to induce emesis. Electrocardiographically, no ectopic rhythm, multiple foci of impulse formation, various forms of aberrant QRS complexes, and terminal ventricular fibrillation occur as the lethal dose is slowly approached. The evidence in cats is therefore not indicative of any digitalis-like action of the three substances.

Submitted on December 27, 1941




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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.