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Journal of Pharmacology And Experimental Therapeutics, Vol. 74, Issue 4, 372-380, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGY AND CHEMISTRY OF SUBSTANCES WITH CARDIAC ACTIVITY I. EFFECT OF UNSATURATED LACTONES ON THE ISOLATED FROG HEART

O. KRAYER 1, R. MENDEZ 1, E. MOISSET DE ESPANÉS 1, and R. P. LINSTEAD 1

1 From the Department of Pharmacology, Harvard Medical School and the Converse Laboratory of the Department of Chemistry, Harvard University

The action on the isolated frog heart has been studied of four unsaturated lactones, namely, betaggr-angelicalactone, agrbeta-angelicalactone, crotonolactone ggr-acetic acid, and methyl ester of crotonolactone ggr-acetic acid.

They cause an increase in the amplitude of contraction followed by a period of diminished relaxation of the ventricle which terminates in systolic standstill.

The angelicalactones improve the activity of the heart made hypodynamic by perfusion with calcium-poor salt solution.

A quantitative comparison of the systolic action showed that the betaggr-angelicalactone is considerably more potent than the three agrbeta-unsaturated lactones.

Submitted on December 27, 1941






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.