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Journal of Pharmacology And Experimental Therapeutics, Vol. 74, Issue 3, 319-323, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

HEMODYNAMIC EFFECTS OF INTRAVENOUS MORPHINE AND PENTOTHAL SODIUM

EMANUEL M. PAPPER 1 and STANLEY E. BRADLEY 1

1 From the Departments of Anesthesia, Medicine and Physiology, New York University College of Medicine, New York City

1. Circulatory studies of the effect of morphine and pentothal sodium given intravenously in normal man are described.

2. Morphine intravenously in therapeutic doses (10 mgm.) has no significantly consistent effect on the cardiovascular system (stroke volume, heart rate, blood pressure and peripheral resistance).

3. Pentothal sodium intravenously, in doses of 0.5 gm. given in 53 seconds and 1.0 gm. in 65 seconds, has little circulatory effect in normal man. In a single instance, a dose of 1.0 gm. given intravenously over a period of 30 seconds produced transient respiratory arrest. Marked vasoconstriction and bradycardia occurred at first, followed rapidly by vasodilatation, with no significant change in cardiac output before asphyxial changes supervened.

Submitted on December 17, 1941




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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.