THE EFFECT OF SYMPATHOMIMETIC AMINES ON PANCREATIC SECRETION

¹ From the Department of Physiology and Pharmacology, Northwestern University Medical School, Chicago

A series of 27 sympathomimetic amines has been tested for their effect on pancreatic secretion. Twenty-one of these compounds inhibited the secretion evoked by continuous secretin stimulation. The mechanism whereby this took place is probably on a vasoconstrictor basis. Seven of the compounds stimulated pancreatic secretion; these were all structurally similar to the extent of hydroxylation of the benzene ring in specific positions, an unsubstituted carbon atom in justaposition to the ring, and a primary or secondary amino nitrogen. Methylation of the hydroxyl groups leaves the secretory potency attenuated but not abolished. The type of stimulation evidenced by these compounds differs from secretin stimulation.