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Journal of Pharmacology And Experimental Therapeutics, Vol. 74, Issue 3, 256-261, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

ASSAY OF ANTI-PERNICIOUS ANEMIA LIVER CONCENTRATES BY THE USE OF AN ISOLATED BONE MARROW PREPARATION

NELLO PACE 1 and R. S. FISHER 1

1 From the Department of Physiology and Pharmacology, Medical College of Virginia, Richmond

The in vitro bone marrow assay method for anti-pernicious anemia preparations has been studied. A curve has been constructed showing the relationship between the dilution of liver concentrates at which maximal migration of cells from bone marrow occurred, and the U.S.P. potency of these concentrates. It would appear that this curve may be used for determination of the expected clinical potency of unknown liver extracts.

Submitted on September 9, 1941




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Arch Intern Med, June 1, 1943; 71(6): 854 - 903.
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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.