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Journal of Pharmacology And Experimental Therapeutics, Vol. 74, Issue 3, 239-246, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

THE MECHANISM OF MORPHINE MIOSIS

F. D. McCREA 1, G. S. EADIE 1, and J. E. MORGAN 1

1 From the Department of Physiology and Pharmacology, Duke University School of Medicine, Durham, North Carolina

1. Morphine miosis in the dog is to a large extent dependent on the integrity of the optic nerve.

2. The degree of miosis in both dog and man depends very largely, but not altogether, on the amount of light falling on the eye, so that the effect of morphine appears to be mainly an exaggeration of the light reflex.

3. These effects of morphine are potentiated by doses of prostigmine which are in themselves ineffective.

4. The rate of recovery of the pupil from a brief exposure to a bright light is greatly delayed by morphine but does not appear to be further delayed by prostigmine.

5. The significance of these findings is discussed.

Submitted on July 30, 1941






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.