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Journal of Pharmacology And Experimental Therapeutics, Vol. 74, Issue 2, 163-174, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF CERTAIN SULFONAMIDES, SULFONES AND RELATED PHOSPHORUS COMPOUNDS IN EXPERIMENTAL TUBERCULOSIS

M. I. SMITH 1, E. W. EMMART 1, and B. B. WESTFALL 1

1 From the Division of Chemotherapy, National Institute of Health, Bethesda, Maryland

A series of sulfonamides, sulfones, and certain related phosphorus compounds were examined for tuberculostatic action in vitro. Good inhibition in decreasing order of magnitude was obtained with diaminodiphenylsulfone, diaminodiphenylsulfoxide, sulfathiazole, diaminodiphenylsulfide, sulfadiazine, phosphanilic acid, and promin. Therapeutic tests in experimental animals showed a favorable effect both as regards survival time and retardation of the progress of the disease with diaminodiphenylsulfone, promin, and sulfadiazine. A doubtful effect was obtained with sulfathiazole and bis (dimethyl amino phenyl) phosphinous acid, and an irregular result with phosphanilic acid. The last-named drug is poorly absorbed from the gastrointestinal tract, and it leaves the blood stream rather rapidly on intravenous or subcutaneous injection, making the maintenance of a satisfactory blood level difficult.

Submitted on November 1, 1941




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H. A. REIMANN
INFECTIOUS DISEASES: NINTH ANNUAL REVIEW OF SIGNIFICANT PUBLICATIONS
Arch Intern Med, September 1, 1943; 72(3): 388 - 426.
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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.