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Journal of Pharmacology And Experimental Therapeutics, Vol. 74, Issue 2, 106-113, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

THE URICOSURIC EFFECTS OF CERTAIN POLYHYDRIC ALCOHOLS AND SACCHARIDES

G. P. GRABFIELD 1 and D. SWANSON 1

1 From the Laboratories of Pharmacology and Medicine in the Harvard Medical School, Boston, Massachusetts

1. The effects of intravenous injections of hypertonic solutions of certain polyhydric alcohols and saccharides have been studied in dogs with exteriorized ureters without anesthesia.

2. These drugs produce not only a diuresis but also a marked increase in uric acid and allantoin excretion.

3. All substances causing the increase in purine excretion have the CH2OH grouping at both ends of the chain.

4. This is not accomplished through a nervous mechanism.

5. It is unlikely that the hypertonicity of the solution per se is the cause of uric acid mobilization, since some hypertonic solutions do not produce this result.

Submitted on October 3, 1941






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.