AN IN VITRO STUDY ON THE SYNERGISTIC ACTION OF SULFAMIDO COMPOUNDS AND AZOCHLORAMID UPON VARIOUS PATHOGENIC MICROORGANISMS

¹ From the Laboratories of the Children's Hospital and the Department of Pathology and Bacteriology, University of Buffalo, School of Medicine, Buffalo, New York

An in vitro study on the combined antibacterial activity of sulfamido compounds and azochloramid revealed the following:

1. Azochloramid used in combination with suffanilamide, suffathiazol, and and sulfadiazine may exert greater bacteriostatic activity toward Group A hemolytic streptococcus than does either compound alone in like or somewhat higher concentrations.

2. A slight increase in bacteriostatic activity toward Group D hemolytic streptococcus was obtained when azochloramid was used in conjunction with sulfanilamide.

3. The combined use of azochloramid and sulfanilamide, sulfapyridine, sulfathiazol or sulfadiazine resulted in greater inhibition of growth of penumococcus type I than did that of either drug alone in like or somewhat higher concentrations.

4. The combined use of sulfathiazol or sulfadiazine and azochloramid retarded the growth of staphylococcus aureus hemolyticus to a greater extent than did either drug in like or higher concentrations.

This article has been cited by other articles:

				O. C. BRANTIGAN RESECTION OF THE LUNG IN THE TREATMENT OF PULMONARY TUBERCULOSIS Arch Surg, October 1, 1945; 51(3): 147 - 153. [Abstract] [PDF]

				THE PERSONNEL OF NAVAL LABORATORY RESEARCH UNIT NO ATTEMPTS TO PROTECT AGAINST INFLUENZA VIRUS WITH VARIOUS SULFONAMIDES, ACRIDINES AND ANTIBIOTICS Science, October 15, 1943; 98(2546): 348 - 349. [PDF]

				J. G. BELLOWS CHEMOTHERAPY IN OPHTHALMOLOGY Arch Ophthalmol, June 1, 1943; 29(6): 888 - 903. [Abstract] [PDF]