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Journal of Pharmacology And Experimental Therapeutics, Vol. 74, Issue 1, 37-41, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE FATE OF MORPHINE

FRED W. OBERST 1

1 From the United States Public Health Service Hospital, Lexington, Kentucky

A modified method for the micro-determination of morphine in quantities from 0.03 to 0.2 mgm. by the morphine-molybdate-vanadate procedure has been described. Morphine analyses were made on urine, feces, saliva, gastric contents, perspiration, bile, and blood from morphine addicts, as well as liver obtained at autopsy on two patients who were addicted at the time of death.

Feces, liver, and perspiration contained free morphine; bile contained only bound morphine; urine and gastric contents contained both free and bound morphine; no morphine was found in saliva or blood.

Submitted on September 22, 1941






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.