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Journal of Pharmacology And Experimental Therapeutics, Vol. 73, Issue 4, 468-473, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

SULFAPYBAZINE (2-SULFANILAMIDOPYRAZINE): ITS ANTIPNEUMOCOCCAL ACTIVITY AS COMPARED WITH THAT OF SULFAPYRIDINE, SULFATHIAZOLE AND SULFADIAZINE

L. H. SCHMIDT 1, J. M. RUEGSEGGER 1, CLARA L. SESLER 1, and MORTON HAMBURGER JR. 1

1 From the Institute for Medical Research, Christ Hospital, and the Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio

The antipneumococcal activity of sulfapyrazine was compared with that of sulfadiazine, sulfathiazole and sulfapyridine. Sulfapyrazine was as effective as sulfadiazine against experimental pneumococcal infections and was somewhat more effective than sulfapyridine and sulfathiazole. Sulfapyrazine was only slightly less effective than sulfathiazole in inhibiting the growth of pneumococcus in vitro, and was more effective than either sulfapyridine or sulfadiazine. Sulfapyrazine concentrations in the blood of treated mice were maintained at a uniform level throughout the treatment period. This latter finding, together with the marked growth-inhibiting properties of this drug, probably accounts for its effectiveness against experimental infections.

Submitted on September 19, 1941






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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.