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Journal of Pharmacology And Experimental Therapeutics, Vol. 73, Issue 4, 463-467, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF MECHOLYL, POTASSIUM CHLORIDE AND PROSTIGMINE ON NEUROMUSCULAR ATROPHY AND REGENERATION

H. M. HINES 1, J. D. THOMSON 1, and B. LAZERE 1

1 From the Department of Physiology, State University of Iowa, Iowa City

The daily oral administration of 4.8 mgm. of mecholyl, 47 mgm. of potassium chloride and 0.72 mgm. of prostigmine to adult albino rats with lesions in their tibial nerves neither delayed muscular atrophy nor hastened neuromuscular regeneration. The criteria employed in the studies include quantitative determinations of the weight changes, creatine concentration and strength of the gastrocnemius muscle at various times after denervation. A discussion is included of the reports of other investigators concerning the favorable influence of these drugs on muscular atrophy and recovery from paralysis.

Submitted on September 2, 1941






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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.