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Journal of Pharmacology And Experimental Therapeutics, Vol. 73, Issue 3, 335-342, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF CALCIUM AND STRONTIUM SALTS ON THE ACTION OF SODIUM PENTOBARBITAL

VERSA V. COLE 1

1 From the Laboratory of Pharmacology and Toxicology, Woman's Medical College of Pennsylvania, Philadelphia

1. Both calcium and strontium acetates increased the duration of sodium pentobarbital anesthesia when the salts were given in equimolecular quantities by intraperitoneal injection.

2. Calcium acetate increased the duration of sodium pentobarbital anesthesia when given by vein. Strontium acetate had very little if any effect.

3. Calcium acetate was more toxic to the rat by intraperitoneal injection than strontium acetate.

4. The greater toxicity of the calcium by intraperitoneal injection was shown to be associated with an increased hemoglobin concentration of the blood.

5. Sodium pentobarbital decreased the toxicity of strontium acetate but strontium acetate did not decrease the toxicity of sodium pentobarbital.

Submitted on August 1, 1941






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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.