STUDIES ON A SERIES OF NEW TRIAZOLE DERIVATIVES

¹ From the Department of Pharmacology, Temple University School of Medicine, Philadelphia

1. The antipyretic and analgesic effects of six derivatives of 1-phenyl, 1,2,3-triazole 4-carboxylic acid were compared with that of aminopyrine.

2. 1-phenyl 5-methyl, 1,2,3-triazole, 4-diethyl carboxamide and the corresponding dimethyl derivative were active antipyretics in rats. The sodium salt of 1-phenyl, 5-methyl, 1,2,3-triazole, 4-carboxylic acid and the ethyl ester of 1-phenyl, 5-amino, 1,2,3-triazo1e, 4-carboxylic acid were less efficient antipyretics than the dimethyl and diethyl amides while the di-isobutyl amide was devoid of antipyretic action.

3. The diethyl compound in a nontoxic dose doubled the pain threshold stimulus in cats and was more effective than aminopyrine. The other triazole derivatives in nontoxic doses were less effective than aminopyrine.

4. The dimethyl and diethyl triazoles were twice as toxic in rats as aminopyrine whereas the other members of the present series were less toxic than aminopyrine.

5. Thus far no advantage over aminopyrine has been found for these compounds.