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Journal of Pharmacology And Experimental Therapeutics, Vol. 73, Issue 3, 304-311, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

ACTIONS OF CURARIZING PREPARATIONS IN THE HUMAN

A. M. HARVEY 1 and R. L. MASLAND 1

1 From the Institute of Neurology and the Johnson Foundation, University of Pennsylvania Philadelphia

The actions of curare extract, erythroidine, and quinine methochloride have been compared in the human subject.

All three drugs produce a characteristic clinical picture accompanied by typical changes in the electromyogram.

Mental disturbances characterized by confusion and disorientation occasionally occur with erythroidine and quinine methochloride.

Minor circulatory changes have been observed and appear more severe with quinine methochloride and erythroidine than with curare.

Other toxic manifestations have been described.

Relief of spasticity has been slight, of brief duration, and has not appeared until there was considerable weakness of the extraocular, facial, and pharyngeal muscles.

The severity of metrazol convulsions has been decreased.

Submitted on July 3, 1941




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G. L. Sauvage, F. M. Berger, and V. Boekelheide
The Conversion of beta-Erythroidine to Derivatives of the Desmethoxy Series and Some Pharmacological Properties of Apo-beta-Erythroidine
Science, June 24, 1949; 109(2843): 627 - 628.
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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.