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Journal of Pharmacology And Experimental Therapeutics, Vol. 73, Issue 2, 205-211, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

THE SELENIUM CONTENT OF "NORMAL" URINE

JAMES H. STERNER 1 and VIOLA LIDFELDT 1

1 From the Laboratory of Industrial Medicine, Eastman Kodak Company, Kodak Park, Rochester, New York

1. Selenium was found in a high percentage of the urine specimens obtained from normal, healthy male adults who had no industrial or other obvious selenium exposure. This finding is in contrast to recent references on the subject.

2. The concentrations of selenium averaged from 4 to 5 ggr per 100 cc. of urine, with a range of 0 to 15 ggr.

3. The rate of urinary selenium excretion is relatively constant and is quite independent of the urinary volume, suggesting that selenium is treated by the kidney as a "non-threshold" substance similar to sulfates and creatinine. The mean rate was 2.2 ggr per hour with relatively slight variability.

4. A dietary source of selenium was found in wheat products, with selenium values ranging from 26 to 39 ggr per 100 grams dry weight, or 0.26 to 0.39 parts per million.

5. No harmful effects were observed which could be correlated with the absorption and excretion of such amounts of selenium as were demonstrated in this study.

Submitted on July 16, 1941




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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.