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Journal of Pharmacology And Experimental Therapeutics, Vol. 73, Issue 1, 85-90, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE TOXICITY AND PHARMACOLOGY OF PANTOTHENIC ACID

KLAUS UNNA 1 and JOSEPH G. GRESLIN 1

1 From the Merck Institute for Therapeutic Research, Rahway, N. J.

1. The acute toxicity of calcium pantothenate has been determined in mice and rats following intravenous, intraperitoneal, subcutaneous, and oral administration. The L.D.50 following subcutaneous injection is 2.7 grams per kilogram in mice and 3.4 grams per kilogram in rats.

2. Daily administration of calcium pantothenate over a period of 6 months to monkeys (1 gram per monkey), dogs (50 mgm. per kilogram) and rats (50 and 200 mgm. resp. per rat) failed to produce any toxic manifestations or pathological changes in the organs.

3. The metabolism, the circulatory and respiratory systems, and the smooth muscle organs of normal animals are not influenced by calcium pantothenate.

Submitted on June 11, 1941




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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.