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1 From The Squibb Institute for Medical Research, New Brunswick, N. J.
1. A method is described for the preparation of renal extracts which are capable of reducing the blood pressure of rats with experimental hypertension. A total dose of 58 grams equivalent of fresh hog kidney, injected intramuscularly twice daily for a period of four days, was found to produce a pronounced and prolonged lowering of the blood pressure.
2. Oral administration of similar renal extracts at comparatively high doses failed to produce a comparable effect on the blood pressure.
3. Extracts of beef liver and muscle prepared according to the same procedure as employed for renal extracts, failed to lower the blood pressure in hypertensive rats.
4. The failure of hog renin to produce a lowering of blood pressure in hypertensive rats in our routine four day test seems to militate against the interpretation that the anti-pressor effect of renal extracts might be due to the formation of an anti-renin substance.
Submitted on May 24, 1941
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