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Journal of Pharmacology And Experimental Therapeutics, Vol. 73, Issue 1, 27-32, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

THE LOCAL ANESTHETIC ACTIVITY OF CERTAIN DERIVATIVES OF agr AND beta-NAPHTHOL

EDWIN J. FELLOWS 1, RAYMOND W. CUNNINGHAM 1, and A. E. LIVINGSTON 1

1 From the Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania

1. In the present experiments the hydrochlorides of agr-morpholino methyl-beta naphthol (I), agr-piperidino methyl-beta-naphthol (II), beta-piperidino methyl agr-naphthyl p-aminobenzoate (III), beta-morpholino methyl agr-naphthyl p-aminobenzoate (IV), agr-morpholino methyl beta-naphthyl p-aminobenzoate (V), agr-piperidino-methyl beta-naphthyl benzoate (VI) and agr-piperidino methyl-beta-naphthyl p-aminobenzoate (VII) were found to produce local anesthesia.

2. Compounds I and II produced marked anesthesia intracutaneously in guinea-pigs but caused irritation. Compound II also was more toxic than procaine subcutaneously in guinea pigs. Compounds III, IV and V are very unstable in solution and produce anesthesia of poor depth and variable duration.

3. Compounds VI and VII produced marked anesthesia and VII was found to have an extremely low subcutaneous toxicity. Both compounds produced irritation in corneal and intradermal tests.

Submitted on May 6, 1941






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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.