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Journal of Pharmacology And Experimental Therapeutics, Vol. 72, Issue 3, 409-416, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF SEDATIVE DRUGS ON THE PIAL VESSELS

THEODORE P. SOHLER 1, GLADYS N. LOTHROP 1, and JOAN WILKINSON 1

1 From the Departments of Neuropathology and Neurology, Harvard Medical School, Boston

Intravenous injections of sedative drugs had the following effects on the pial arteries of anesthetized animals:

1. Dial caused chiefly dilation, but the effect was neither constant nor large.

2. Avertin fluid (avertin crystals plus amylene hydrate and water) caused dilation. This response was fairly consistent and of large extent.

3. Avertin crystals (aqueous solution) caused dilation. Occasionally this was followed by a slow constriction of relatively long duration.

4. Amylene hydrate caused dilation, but this was usually complicated by a change in blood pressure.

5. Acetanilide caused no change in calibre, but a definite change in color of the blood in the pial vessels. This change was from red to brownish red with a purple tint—suggestive of cyanosis.

6. Sodium bromide (injected intravenously at ordinary rate) caused no change in diameter of the pial arteries.

Submitted on April 12, 1941






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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.