STUDIES ON SHOCK INDUCED BY HEMORRHAGE II. EFFECT OF THIAMIN ON DISTURBANCES OF CARBOHYDRATE METABOLISM

¹ From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

1. A marked increase in blood keto acids occurs in dogs in which shock has been induced by hemorrhage. This increase is accompanied by hyperglycemia and hyperlactacidemia.

2. Administration of thiamin to these animals is followed by a delayed fall in the elevated blood keto acid values.

3. The increase in survival time and elevation of blood pressure following thiamin administration is much more marked in the locally anesthetized animal than in the animal anesthetized with ether.

4. Ether anesthesia alone may produce a moderate increase in blood keto acids, a hyperglycemia and increased blood lactic acid values. In these dogs also, elevated keto acid values usually fall after thiamin administration.

5. Animals locally anesthetized with procaine solution and not subjected to shock show no rise in keto acids, blood sugar or blood lactic acid.