THE RESPONSE OF SULFAPYRIDINE-RESISTANT PNEUMOCOCCI TO HYDROXYETHYLAPOCUPREINE

¹ From the Institute or Medical Research, Christ Hospital, and the Department of Biological Chemistry, College of Medicine, University of Cincinnati, Cincinnati, Ohio

A comparison was made of the activity of hydroxyethylapocupreine and sulfapyridine against infections in mice with parent and sulfapyridine-fast pneumococci. Infections with the parent organisms were susceptible to treatment with sulfapyridine, whereas infections with the "fast" organisms were not. On the other hand, hydroxyethylapocupreine was equally effective against infections with parent and sulfapyridine-resistant strains. However, hydroxyethylapocupreine was less effective than sulfapyridine against infections with most of the parent organisms.