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Journal of Pharmacology And Experimental Therapeutics, Vol. 72, Issue 3, 306-310, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

FURTHER OBSERVATIONS ON THE ACTION OF DRUGS ON THE CALIBER OF CORONARY VESSELS PAPAVERINE HYDROCHLORIDE, DIGITALIS DERIVATIVES, AMINOPHYLLIN, CAFFEIN, GLUCOSE, CALCIUM GLUCONATE AND METRAZOL

E. LINDNER 1 and L. N. KATZ 1

1 From the Cardiovascular Dept., Michael Reese Hospital, Chicago, Ill.

1. The digitalis derivatives, K-strophanthin, ouabain and digifoline at times have a direct coronary constrictor action even in therapeutic doses.

2. Metrazol and glucose are mild direct coronary dilators.

3. Calcium gluconate, in contrast with the chloride salt which is a powerful dilator of the coronary vessels, does not cause any constant or striking change in coronary caliber except that a mild dilatation occurs with large doses.

4. Aminophyllin and caffein sodium benzoate are consistently direct coronary dilators, the aminophyllin being the more powerful.

5. Papaverine hydrochloride is a powerful long-lasting direct coronary dilating agent. This and its tendency to prevent ventricular fibrillation probably explain its clinical benefits.

Submitted on April 25, 1941




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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.