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Journal of Pharmacology And Experimental Therapeutics, Vol. 72, Issue 3, 291-297, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

THE MODE OF ACTION OF NEOPRONTOSIL IN STREPTOCOCCUS INFECTIONS IN MICE

J. T. LITCHFIELD JR. 1, H. J. WHITE 1, and E. K. MARSHALL JR. 1

1 From the Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University, Baltimore

The therapeutic activity of neoprontosil has been compared to that of sulfanilamide in a streptococcus infection in mice. Essentially the same blood concentration-time curve of sulfanilamide was obtained from both drugs by use of the drug-diet method of therapy. The results show that the entire therapeutic activity of neoprontosil depends on the sulfanilamide formed from it.

Submitted on April 16, 1941






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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.