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Journal of Pharmacology And Experimental Therapeutics, Vol. 72, Issue 1, 112-122, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

THE RELATIONSHIP BETWEEN THE IN VITRO AND THE IN VIVO ACTIVITY OF SULFONAMIDE COMPOUNDS

H. J. WHITE 1, A. CALVIN BRATTON 1, J. T. LITCHFIELD JR. 1, and E. K. MARSHALL JR. 1

1 Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University, Baltimore

A qualitative comparison of the in vitro and in vivo activity on beta-hemo1ytic streptococcus of 126 compounds consisting of sulfanilamide derivatives, sulfonamides, suifones, sulfoxides, sulfides and certain miscellaneous compounds has been made. It has been shown that no compound is active in vivo unless it is active in vitro or can be decomposed in the animal body to a compound which would be active in vitro, and that compounds can be active in vitro but inactive in vivo.

Submitted on March 21, 1941




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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.