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Journal of Pharmacology And Experimental Therapeutics, Vol. 71, Issue 4, 331-335, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

THE PIAL CIRCULATION OF NORMAL, NON-ANESTHETIZED ANIMALS PART II. THE EFFECTS OF DRUGS, ALCOHOL AND CO2

THEODORE P. SOHLER 1, GLADYS N. LOTHROP 1, and HENRY S. FORBES 1

1 From the Departments of Neuropathology and Neurology, Harvard Medical School, Boston

In animals with permanently installed cranial windows the effects of certain drugs on the pial arteries were as follows:

Avertin and carbon dioxide caused vasodilation.

Alcohol, dial, nembutal, metrazol and acetanilide were followed by little if any immediate change in vessel caliber.

Acetanilide, by mouth, caused cyanosis visible in the pial circulation.

The presence or absence of general anesthesia did not appear to influence the results noticeably, but recent operative exposure seemed to increase the dilator effect of some drugs.

Submitted on January 7, 1941




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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.