THE PHARMACOLOGY OF SOME DERIVATIVES OF MONO ALPHA SECONDARY FURFURYLAMINE AND OF DI-ALPHA FURFURYL TERTIARY AMINE

¹ From the Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York

The foregoing data indicate that the series of furfuryl-amine derivatives listed has little pharmacological activity and that the order of toxicity is low. The toxicity increases with the length of the substituents on the nitrogen molecule. Four of the six mono-furfuryl-amines were less toxic than the di-furfuryl-amine derivatives.

Amyl-furfuryl-amine, and methyl- and ethyl-di-furfuryl-amines stimulated the rabbit uterus and depressed the rabbit intestine, suggesting that they may possess some degree of "sympathomimicity." If so, the action is predominantly upon the motor mechanism because the effect upon the uterus is abolished but not reversed by ergotoxine and the non-pregnant cat uterus is not inhibited. In this respect these substances superficially resemble ephedrine. On the other hand, these drugs do not stimulate the frog heart nor do they raise but in large doses depress the blood pressure of atropinized cats. The other members of the mono-furfuryl-amines are inert while the others of the di-furfuryl-amines depress smooth muscles at all times.