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Journal of Pharmacology And Experimental Therapeutics, Vol. 71, Issue 3, 268-272, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF SODIUM DIPHENYL HYDANTOINATE (DILANTIN) ON VITAMIN C LEVEL IN TISSUES AND VITAMIN C EXCRETION IN RATS

MILES E. DRAKE 1, CHARLES M. GRUBER 1, and VICTOR G. HAURY 1

1 From the Department of Pharmacology, Jefferson Medical College, Philadelphia, Pennsylvania

1. Sodium diphenyl hydantoinate (Dilantin) given orally to albino rats causes an increase in the excretion of ascorbic acid in the urine as determined by the sodium 2-6 dichlorobenzenoneindophenol method.

2. The maximum excretion of vitamin C in the urine following the oral administration of dilantin is reached on the fourth day, returning to its control level on the fifth to seventh day.

3. The body supply of vitamin C appears to be gradually decreased by the administration of dilantin as indicated by our tissue studies.

Submitted on November 16, 1940




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Arch Intern Med, February 1, 1942; 69(2): 277 - 343.
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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.